舌尖伸入湿嫩蜜汁呻吟,国产一二级视频在线观看,久久久99亚洲毛片久久,99久久精品国产综合精品

當(dāng)前位置:首頁(yè)  >  技術(shù)文章  >  RGDSP功能化肽水凝膠,促進(jìn)人羊膜間充質(zhì)干細(xì)胞創(chuàng)面愈合

RGDSP功能化肽水凝膠,促進(jìn)人羊膜間充質(zhì)干細(xì)胞創(chuàng)面愈合

更新時(shí)間:2025-01-27  |  點(diǎn)擊率:489

202410月,貴州省細(xì)胞工程重點(diǎn)實(shí)驗(yàn)室,遵義醫(yī)學(xué)院附屬醫(yī)院,遵義醫(yī)科大學(xué)附屬醫(yī)院臨床干細(xì)胞研究所,湖北醫(yī)科大學(xué)附屬太和醫(yī)院創(chuàng)面修復(fù)與皮膚外科 (Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, China,The Clinical Stem Cell Research Institute, Affiliated Hospital of Zunyi Medical University, Zunyi, China,Department of Wound Repair and Dermatologic Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, China) Wei Wei老師研究團(tuán)隊(duì)在《Frontiers in Bioengineering and Biotechnology》上發(fā)表論文:

RGDSP-functionalized peptide hydrogel stimulates growth factor secretion via integrin αv/PI3K/AKT axis for improved wound healing by human amniotic mesenchymal stem cells"

 

RGDSP功能化肽水凝膠通過(guò)整合素αv/PI3K/AKT軸刺激生長(zhǎng)因子分泌,促進(jìn)人羊膜間充質(zhì)干細(xì)胞創(chuàng)面愈合"

 

Abstract

The wound healing process involves communication among growth factors, cytokines, signaling pathways, and cells in the extracellular matrix, with growth factors acting as key regulators. Although stem cells can promote wound healing by secreting diverse growth factors, their therapeutic potential is hindered by poor survival and engraftment. Mimicking the stem cell-matrix interactions can improve stem cell survival, regulate their fate, and even enhance their paracrine effects. This study investigated the use of composite RGDmix hydrogel, which can support the survival and proliferation of human amniotic mesenchymal stem cells (hAMSCs), and effectively increase the expression of various growth factors, thereby promoting wound re-epithelialization, angiogenesis, and epidermal maturation. At last, the specific role of integrin αv and PI3K/AKT signaling pathways in the secretion of growth factors were examined by silencing them in vitro and in vivo. Results suggested that the RGDmix hydrogel improved the secretion of growth factors by hAMSCs through the RGDSP/integrin αv/PI3K/AKT axis, thereby enhancing the therapeutic effect in wound healing.


摘要:

傷口愈合過(guò)程涉及生長(zhǎng)因子、細(xì)胞因子、信號(hào)通路和細(xì)胞外基質(zhì)細(xì)胞之間的交流,其中生長(zhǎng)因子是關(guān)鍵的調(diào)節(jié)因子。雖然干細(xì)胞可以通過(guò)分泌多種生長(zhǎng)因子促進(jìn)傷口愈合,但其治療潛力受到生存和植入性差的阻礙。模擬干細(xì)胞與基質(zhì)的相互作用可以提高干細(xì)胞的存活率,調(diào)節(jié)其命運(yùn),甚至增強(qiáng)其旁分泌作用。本研究研究了復(fù)合RGDmix水凝膠能夠支持人羊膜間充質(zhì)干細(xì)胞(hAMSCs)的存活和增殖,并有效增加各種生長(zhǎng)因子的表達(dá),從而促進(jìn)創(chuàng)面再上皮化、血管生成和表皮成熟。最后,通過(guò)體外和體內(nèi)實(shí)驗(yàn),研究整合素αvPI3K/AKT信號(hào)通路在生長(zhǎng)因子分泌中的具體作用。結(jié)果表明,RGDmix水凝膠通過(guò)RGDSP/integrin αv/PI3K/AKT軸促進(jìn)hAMSCs分泌生長(zhǎng)因子,從而增強(qiáng)傷口愈合的治療效果。

 

該論文中,hAMSCs的體外培養(yǎng)是使用Ausbian特級(jí)胎牛血清完成的。


极品人妻老师的娇喘呻吟| 我和闺蜜在ktv被八人伦| 99热最新地址在线观看| 国产精品人妻一码二码| 久久亚洲熟女cc98cm| 视频一区视频二区日韩精品| WWW国产精品内射老熟女| 国产激情久久久久影院老熟女免费 | 中国成熟妇女毛茸茸| 亚洲成人动漫视频在线观看 | 我要农村去姑娘的逼毛片| 年轻的小婊2韩剧中文版| 精品人妻无码专区在线视频| 女人乱人伦国产在线观看| 亚洲欧美日韩综合另类一区| 天堂av在线最新版在线 | 啊啊啊啊啊好痛黄色视频| 大香蕉视频在线观看精品| 亚洲成L人在线观看线路| 东北女人毛多水多牲交视频| 人妻 自慰 偷窥 无码| 伊人久久大香线蕉AV不卡| 欧美激情综合五月色丁香| 无套内谢少妇毛片a片软件| 精品亚洲一区二区三区四区五区 | 中文字幕丰满乱孑伦无码专区| 自拍偷自拍亚洲精品播放| 欧美国产精品XXXXB| 亚洲色欲色欲www在线丝| 适合女士自慰时看的黄文 | 7777久久亚洲中文字幕| 九九热在线免费在线观看| 97re热在线视频播放| 一受多攻同做h嗯啊巨肉| 97人妻精品专区久久久久| 亚洲中文字幕无码AV| 日本无码小泬粉嫩精品图| 欧美日韩亚洲精品第一页| 国产精品美女久久久亚洲| 成人精品一区二区三区中文字幕| 丰满少妇在线观看网站|